![A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease: Molecular Therapy - Nucleic Acids A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease: Molecular Therapy - Nucleic Acids](https://www.cell.com/cms/attachment/a29bd97a-176e-4588-b23a-baf24c7df422/fx1_lrg.jpg)
A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease: Molecular Therapy - Nucleic Acids
![Molecular Genesis Huntington's Disease Illustration Expansion Cag Trinucleotide Sequence Htt Stock Photo by ©katerynakon 474065062 Molecular Genesis Huntington's Disease Illustration Expansion Cag Trinucleotide Sequence Htt Stock Photo by ©katerynakon 474065062](https://st2.depositphotos.com/5316818/47406/i/1600/depositphotos_474065062-stock-photo-molecular-genesis-huntington-disease-illustration.jpg)
Molecular Genesis Huntington's Disease Illustration Expansion Cag Trinucleotide Sequence Htt Stock Photo by ©katerynakon 474065062
![Molecular genesis of Huntington's disease, illustration. Expansion of the CAG trinucleotide sequence in the htt gene causes production of mutated Huntingtin protein leading to neurodegeneration, atrophy of brain basal ganglia, involuntary movements Molecular genesis of Huntington's disease, illustration. Expansion of the CAG trinucleotide sequence in the htt gene causes production of mutated Huntingtin protein leading to neurodegeneration, atrophy of brain basal ganglia, involuntary movements](https://c8.alamy.com/zooms/9/4cadf639fffb408ba2898fffe80e69cc/2gg0cpc.jpg)
Molecular genesis of Huntington's disease, illustration. Expansion of the CAG trinucleotide sequence in the htt gene causes production of mutated Huntingtin protein leading to neurodegeneration, atrophy of brain basal ganglia, involuntary movements
![Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS: Molecular Therapy - Nucleic Acids Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS: Molecular Therapy - Nucleic Acids](https://www.cell.com/cms/attachment/527571e7-f108-4b9a-b97f-6332eae501c9/fx1_lrg.jpg)
Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS: Molecular Therapy - Nucleic Acids
![In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease - ScienceDirect In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2405844021001936-gr1.jpg)
In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease - ScienceDirect
![Huntington's Disease Research: Shutting down the mutant gene – HudsonAlpha Institute for Biotechnology Huntington's Disease Research: Shutting down the mutant gene – HudsonAlpha Institute for Biotechnology](https://s3.amazonaws.com/hudsonalpha/wp-content/uploads/2021/06/09113747/EDA_HuntingtnGenes.jpeg)
Huntington's Disease Research: Shutting down the mutant gene – HudsonAlpha Institute for Biotechnology
A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity | PLOS Genetics
The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain | PLOS ONE
![Molecular Genesis Huntington's Disease Illustration Expansion Cag Trinucleotide Sequence Htt Stock Photo by ©katerynakon 474065032 Molecular Genesis Huntington's Disease Illustration Expansion Cag Trinucleotide Sequence Htt Stock Photo by ©katerynakon 474065032](https://st2.depositphotos.com/5316818/47406/i/1600/depositphotos_474065032-stock-photo-molecular-genesis-huntington-disease-illustration.jpg)
Molecular Genesis Huntington's Disease Illustration Expansion Cag Trinucleotide Sequence Htt Stock Photo by ©katerynakon 474065032
![Structure and putative protein binding properties of the CAG repeats... | Download Scientific Diagram Structure and putative protein binding properties of the CAG repeats... | Download Scientific Diagram](https://www.researchgate.net/publication/7845090/figure/fig1/AS:277751803203584@1443232598551/Structure-and-putative-protein-binding-properties-of-the-CAG-repeats-hairpins-A.png)
Structure and putative protein binding properties of the CAG repeats... | Download Scientific Diagram
![IJMS | Free Full-Text | Decreased Interactions between Calmodulin and a Mutant Huntingtin Model Might Reduce the Cytotoxic Level of Intracellular Ca2+: A Molecular Dynamics Study IJMS | Free Full-Text | Decreased Interactions between Calmodulin and a Mutant Huntingtin Model Might Reduce the Cytotoxic Level of Intracellular Ca2+: A Molecular Dynamics Study](https://pub.mdpi-res.com/ijms/ijms-22-09025/article_deploy/html/images/ijms-22-09025-ag.png?1629773480)
IJMS | Free Full-Text | Decreased Interactions between Calmodulin and a Mutant Huntingtin Model Might Reduce the Cytotoxic Level of Intracellular Ca2+: A Molecular Dynamics Study
![Frontiers | Protein Aggregation Inhibitors as Disease-Modifying Therapies for Polyglutamine Diseases Frontiers | Protein Aggregation Inhibitors as Disease-Modifying Therapies for Polyglutamine Diseases](https://www.frontiersin.org/files/Articles/621996/fnins-15-621996-HTML/image_m/fnins-15-621996-g001.jpg)
Frontiers | Protein Aggregation Inhibitors as Disease-Modifying Therapies for Polyglutamine Diseases
![Discovery of a potent small molecule inhibiting Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein | Scientific Reports Discovery of a potent small molecule inhibiting Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein | Scientific Reports](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41598-019-53410-z/MediaObjects/41598_2019_53410_Fig1_HTML.png)
Discovery of a potent small molecule inhibiting Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein | Scientific Reports
![Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide: Molecular Therapy - Nucleic Acids Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide: Molecular Therapy - Nucleic Acids](https://www.cell.com/cms/attachment/b31ee508-6c16-452e-8968-c550ba17acec/gr1_lrg.jpg)
Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide: Molecular Therapy - Nucleic Acids
![Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice - ScienceDirect Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S089662732200006X-fx1.jpg)
Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice - ScienceDirect
![PolyQ-independent toxicity associated with novel translational products from CAG repeat expansions | bioRxiv PolyQ-independent toxicity associated with novel translational products from CAG repeat expansions | bioRxiv](https://www.biorxiv.org/content/biorxiv/early/2019/12/20/2019.12.20.884254/F4.large.jpg)